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Intra-uterine bupivacaine and levobupivacaine


  • There is no commercial affiliation.

Dr Ayse Mizrak, Department of Anesthesiology and Reanimation, Gaziantep University Medical Faculty, 27310 Sahinbey, Gaziantep, Turkey. Email:


Aim:  The study aimed to compare the effect of intrauterine bupivacaine and levobupivacaine with placebo in reducing the post-procedure discomfort owing to pain caused by suction endometrial sampling.

Methods:  This study was conducted on randomly selected 45 women with abnormal uterine bleeding and who had undergone outpatient hysteroscopy and endometrial biopsy under sedation with propofol 0.5 mg/kg. The study was performed using 5 mL of bupivacaine 0.5% (Group B, = 15) or levobupivacaine 0.5% (Group L, = 15) or placebo solution (Group C, = 15) intrauterine via a catheter over a 5 min period after suction endometrial sampling. The number of patients with visual analogue scale >3, total postoperative analgesic requirements, satisfaction of patients and adverse events were measured. Nonparametric and parametric data were analysed using Kruskal–Wallis and one-way anova tests respectively.

Results:  Women in Groups L and B had statistically significantly less pain than the women in Group C (= 0.03). When compared with placebo, five ml of bupivacaine 0.5% and levobupivacaine 0.5% respectively were recorded to decrease the incidence of postoperative analgesic consumption from 41 to 35% (= 0.01). The satisfaction score of the patients in Group L was significantly higher than that of the patients in Group C (= 0.03).

Conclusion:  Intrauterine levobupivacaine or bupivacaine is effective in decreasing the pain associated with the endometrial biopsy and curettage under propofol sedation.