Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women
Article first published online: 17 MAR 2010
© 2010 The Authors. Journal compilation © 2010 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Australian and New Zealand Journal of Obstetrics and Gynaecology
Volume 50, Issue 2, pages 189–193, April 2010
How to Cite
MA, L., LIN, S., CHEN, R., ZHANG, Y., CHEN, F. and WANG, X. (2010), Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women. Australian and New Zealand Journal of Obstetrics and Gynaecology, 50: 189–193. doi: 10.1111/j.1479-828X.2010.01137.x
- Issue published online: 13 APR 2010
- Article first published online: 17 MAR 2010
- Received 11 July 2009; accepted 10 January 2010.
- premenstrual syndrome;
- reduction percentage of symptom score;
- Vitex agnus castus
Objectives: To assess therapeutic effect of an extract of Vitex agnus castus (VAC, BNO 1095) in premenstrual syndrome (PMS) in Chinese women.
Design: It was a prospective, randomised, double-blind, placebo-controlled study carried out in China. Eligible patients were treated with VAC extract or placebo for three cycles. Symptoms were documented with PMS diary (PMSD), a daily rating scale with 17 items. Main efficacy variable was the reduction percentage of 17 symptom score documented in PMSD during the luteal phase of the third treatment cycle.
Results: A total of 67 patients were enrolled and randomly assigned to VAC group or placebo group. Of these, 64 patients completed the study (31 vs. 33). All the 17 symptoms showed a significantly greater improvement with VAC than placebo (P < 0.05) except lower abdominal cramping (P > 0.05).
Conclusion: Vitex agnus castus is more effective than placebo in the treatment of moderate-to-severe PMS in Chinese women, especially in symptoms of negative effect and insomnia.