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Keywords:

  • Cushing’s syndrome;
  • hypercortisolism;
  • pregnancy-induced Cushing’s syndrome

Pregnancy in women with Cushing’s syndrome (CS) is uncommon. It is associated with significant maternal and fetal complications. Pregnancy-induced Cushing’s syndrome is exceptionally rare with fewer than ten cases reported in the world literature and none in Australia or New Zealand. We describe a woman with possible recurrent pregnancy-induced CS complicating five pregnancies over a 7-year period. We discuss the changes in the hypothalamic–pituitary–adrenal axis during normal pregnancy together with the diagnosis, aetiology and management of CS in pregnancy.