Treatment of refractory tardive dyskinesia with donepezil in an elderly patient with depression
Article first published online: 19 NOV 2008
© 2008 The Authors. Journal compilation © 2008 Japanese Psychogeriatric Society
Volume 8, Issue 4, pages 196–198, December 2008
How to Cite
YOSHIMI, A., TOGO, T., SUGIYAMA, N., UEHARA, K., OTSUKA, T., KARASHIMA, A. and HIRAYASU, Y. (2008), Treatment of refractory tardive dyskinesia with donepezil in an elderly patient with depression. Psychogeriatrics, 8: 196–198. doi: 10.1111/j.1479-8301.2008.00245.x
- Issue published online: 19 NOV 2008
- Article first published online: 19 NOV 2008
- Received 5 November 2007; accepted 26 May 2008.
- involuntary movement;
- oral dyskinesia;
- tardive dyskinesia
Tardive dyskinesia (TD) is a neurological disorder caused by the prolonged administration of dopamine antagonists, usually antipsychotics and especially first-generation antipsychotics. Herein, we report on an elderly patient suffering from TD with depression induced by amoxapine, an antidepressant that antagonizes dopamine receptors. This case report demonstrates the therapeutic effect of donepezil even for TD due to amoxapine, corroborating the view that donepezil is beneficial for the treatment of TD induced by dopamine antagonists. A randomized placebo-controlled double-blind trial is required to confirm the usefulness of donepezil in the treatment of dopamine antagonist-induced TD.