Managing abnormal eating behaviours in frontotemporal lobar degeneration patients with topiramate

Authors

  • Shunichiro SHINAGAWA,

    Corresponding author
    1. Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
      Dr Shunichiro Shinagawa, MD, PhD, Department of Psychiatry, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. Email: shinagawa@jikei.ac.jp
    Search for more papers by this author
  • Norifumi TSUNO,

    1. Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Search for more papers by this author
  • Kazuhiko NAKAYAMA

    1. Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan
    Search for more papers by this author

Dr Shunichiro Shinagawa, MD, PhD, Department of Psychiatry, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan. Email: shinagawa@jikei.ac.jp

Abstract

Abnormal eating behaviours are specific to frontotemporal lobar degeneration and increase caregiver burden. Topiramate, an anticonvulsant, suppresses cravings for alcohol and other substances and is a potential treatment for binge eating. However, there are few reports on topiramate efficacy for abnormal eating behaviours in frontotemporal lobar degeneration patients. We present three Japanese frontotemporal lobar degeneration patients with abnormal eating behaviours. Topiramate was effective, especially for compulsive eating, in cases with distinct lobar atrophy, but not for all abnormal eating behaviours.

Ancillary