Pathogenetic heterogeneity of restless legs syndrome in Parkinson's disease



This article is corrected by:

  1. Errata: CORRIGENDUM Volume 7, Issue 2, 128, Article first published online: April 2009

Dr Takashi Nomura, Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago 683-8504, Japan. Email:


In order to clarify the pathogenetic heterogeneity of restless legs syndrome (RLS), we compared the clinical characteristics of RLS between six patients with young-onset Parkinson's Disease (PD) and 30 with elderly-onset PD. Young-onset PD showed longer periods from the onset of PD to that of RLS than elderly-onset PD, despite a similar severity between the two groups. The rate of subjects with disappearance of RLS at the follow-up observations was significantly higher in the former group. These results suggested that RLS in young-onset PD could be milder and more transient than that in elderly-onset PD.