Author's note: This review article is based upon the Honorary President Lecture, presented at the Hayaishi Memorial Symposium at the Joint Congress of the 6th Congress of Asian Sleep Research Society, the 34th Annual Meeting of Japanese Society of Sleep Research, and the 16th Annual Meeting of Japanese Society of Chronobiology, held on 26 Ootober 2009 at the Osaka International Convention Center, Osaka, Japan. I express my most sincere thanks to President Masako Okawa, President Yoshihiro Urade, and President Hitoshi Okamura for their kind invitation extended to me to present this lecture and to contribute this review article to Sleep and Biological Rhythms. The original title of the lecture was “Humoral mechanisms of sleep–wake regulation – commemorating the centennial anniversary of the discovery of endogenous sleep substances.”
Humoral mechanisms of sleep–wake regulation: Historical review of prostaglandin D2 and related substances
Version of Record online: 24 FEB 2011
© 2011 The Author. Sleep and Biological Rhythms © 2011 Japanese Society of Sleep Research
Sleep and Biological Rhythms
Special Issue: SLEEP SUBSTANCES, SLEEP ARCHITECTURE & SLEEP SOCIOLOGY -Centennial Anniversary of the First Discovery of Sleep Substances by Kuniomi Ishimori-
Volume 9, Issue Supplement s1, pages 3–9, February 2011
How to Cite
HAYAISHI, O. (2011), Humoral mechanisms of sleep–wake regulation: Historical review of prostaglandin D2 and related substances. Sleep and Biological Rhythms, 9: 3–9. doi: 10.1111/j.1479-8425.2010.00448.x
- Issue online: 24 FEB 2011
- Version of Record online: 24 FEB 2011
- Accepted 21 April 2010.
- prostaglandin (PG) D2 and E2;
- sleep and wake
Sleep is perhaps one of the most important and yet least understood of the physiological functions of the brain. Sleep is essential for life, but we still cannot answer even the simplest questions about sleep, such as “what is sleep?,”“why do we need to sleep?,” and most importantly, “where and how are sleep and arousal regulated?” In the mean time, the number of sleep-disorder patients has recently been increasing exponentially and now exceeds more than 25% of the total population in most countries. More than 107 different sleep disorders have now been described, but in most instances, their etiologies are not yet clearly understood, simply because basic sleep science research has really only just begun. In the early 1980s, my colleagues and I at Kyoto University serendipitously discovered that prostaglandin D2 induced physiological sleep in rats and monkeys, and subsequently we elucidated the molecular mechanisms underlying sleep–wake regulation by prostaglandins D2 and E2. In this review, I start with a brief historical account, follow it by our ongoing work on prostaglandins and sleep, and finally close with a few remarks on the future prospects of sleep science.