Plasma proteomic analysis in patients with obstructive sleep apnea syndrome
Article first published online: 2 OCT 2012
© 2012 The Authors. Sleep and Biological Rhythms © 2012 Japanese Society of Sleep Research
Sleep and Biological Rhythms
Volume 10, Issue 4, pages 336–339, October 2012
How to Cite
SHINOHARA, M., SAKURAI, T., SAKAO, S., YANO, T., BECKER, C., MATSUMOTO, C., OGAWA, K., FUKUTAKE, M., YAMAMOTO, M. and TATSUMI, K. (2012), Plasma proteomic analysis in patients with obstructive sleep apnea syndrome. Sleep and Biological Rhythms, 10: 336–339. doi: 10.1111/j.1479-8425.2012.00536.x
- Issue published online: 2 OCT 2012
- Article first published online: 2 OCT 2012
- Accepted 27 December 2011.
- immune system;
- sleep apnea syndrome
Proteomics is one of the strategies to evaluate molecular mechanisms underlying obstructive sleep apnea syndrome (OSAS). To examine the pathophysiological significance of plasma proteomics in OSAS, the plasma samples from severe OSAS patients (n= 6) with obese (BMI > 30) and non-OSAS patients (n= 6) with non-obese (BMI < 30) were subjected to proteomic profiling. Many proteins regarding inflammation and immune response, including complement proteins, two acute-phase reactants ceruloplasmin and serum amyloid P-component, were found to be highly expressed in severe OSAS patients. Protein changes responsible for immune modulation and inflammation may be a feature of OSAS patients.