Insomnia and shift-work sleep disorder: A crosstalk between glutamate excitotoxicity and decreased GABAergic neurotransmission?


Dr Raffaella Mormile, Division of Pediatrics and Neonatology, Moscati Hospital, Via A. Gramsci, 3 81031 Aversa, Italy. Email:


We hypothesize that insomnia linked to shift-work sleep disorders may be caused by decreased GABAergic transmission as a consequence of glutamate excitotoxicity and that, in this context, glutamate transporters could be candidates as a new therapeutic target for insomnia.