Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African-American Cocaine Abusers
Version of Record online: 18 FEB 2010
2003 American Academy of Addiction Psychiatry
The American Journal on Addictions
Volume 12, Issue 5, pages 432–447, October-December 2003
How to Cite
Patkar, A. A., Gottheil, E., Berrettini, W. H., Hill, K. P., Thornton, C. C. and Weinstein, S. P. (2003), Relationship between Platelet Serotonin Uptake Sites and Measures of Impulsivity, Aggression, and Craving among African-American Cocaine Abusers. The American Journal on Addictions, 12: 432–447. doi: 10.1111/j.1521-0391.2003.tb00486.x
- Issue online: 18 FEB 2010
- Version of Record online: 18 FEB 2010
- Received June 25, 2001; revised August 28, 2001; accepted October 3, 2001.
We investigated whether platelet-tritiated paroxetine binding, a measure of serotonin uptake sites, and behavioral measures of impulsivity, aggression, and craving differed between cocaine-dependent subjects and controls and whether paroxetine binding was related to these behavioral measures. One hundred and five African-American cocaine-dependent out-patients and 44 African-American controls were studied. Tritiated paroxetine binding sites on platelets were assayed, and standardized assessments of impulsivity, aggression, and craving were performed. The Bmax values of paroxetine binding were significantly reduced among cocaine patients compared to controls. Cocaine patients showed significantly higher scores on certain measures of sensation seeking, impulsivity, and aggression as compared to controls. Furthermore, paroxetine binding showed a significant negative correlation with most measures of sensation seeking, impulsivity, and aggression—though not craving—among cocaine patients. Our findings indicate that densities of serotonin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions.