Prospective Assessment of Transient Cocaine-Induced Psychotic Symptoms in a Clinical Setting

Authors

  • Florence Vorspan MD, MSc,

    1. Neuropsychopharmacologie des Addictions, INSERM U705, CNRS UMR 8206, Université PRES Sorbonne-Paris Cité, Paris, France
    2. Pôle Addictologie-Toxicologie-Psychiatrie, Hôpital Fernand Widal, AP-HP, Paris, France
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  • Vanessa Bloch PharmD, PhD,

    1. Neuropsychopharmacologie des Addictions, INSERM U705, CNRS UMR 8206, Université PRES Sorbonne-Paris Cité, Paris, France
    2. Pôle Addictologie-Toxicologie-Psychiatrie, Hôpital Fernand Widal, AP-HP, Paris, France
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  • Georges Brousse MD, PhD,

    1. Neuropsychopharmacologie des Addictions, INSERM U705, CNRS UMR 8206, Université PRES Sorbonne-Paris Cité, Paris, France
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  • Laetitia Bellais MA, MSc,

    1. Neuropsychopharmacologie des Addictions, INSERM U705, CNRS UMR 8206, Université PRES Sorbonne-Paris Cité, Paris, France
    2. Pôle Addictologie-Toxicologie-Psychiatrie, Hôpital Fernand Widal, AP-HP, Paris, France
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  • Julien Gascon MA,

    1. Association EGO, Paris, France
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  • Jean-Pierre Lépine MD

    1. Neuropsychopharmacologie des Addictions, INSERM U705, CNRS UMR 8206, Université PRES Sorbonne-Paris Cité, Paris, France
    2. Pôle Addictologie-Toxicologie-Psychiatrie, Hôpital Fernand Widal, AP-HP, Paris, France
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Dr. Vorspan, Pôle Addictologie-Toxicologie-Psychiatrie, Hôpital Fernand Widal, AP-HP, 200 rue du Faubourg Saint Denis, F-75010 Paris. E-mail: florence.vorspan@lrb.aphp.fr.

Abstract

Cocaine use is associated with the occurrence of transient psychotic symptoms. Sixteen poly-substance abusers already in treatment, who were diagnosed with crack dependence, were assessed twice: at baseline and after 3 weeks of medical management specifically aimed at cocaine abstinence. The psychotic symptoms were assessed with the French version of the Scale for Assessment of Positive Symptoms–Cocaine-Induced Psychosis (SAPS-CIP). There was a decrease of both cocaine intake and psychotic symptoms at week 3 (Wilcoxon's Z, p < .001 and .028, respectively). Furthermore, there was a significant correlation between psychotic symptoms and dose reduction (r2= .49, Spearman's ρ= .613, p < .012). (Am J Addict 2011;20:535–537)

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