Genetic Association of GABA-A Receptor Alpha-2 and Mu Opioid Receptor with Cocaine Cue-Reactivity: Evidence for Inhibitory Synaptic Neurotransmission Involvement in Cocaine Dependence
Article first published online: 10 AUG 2012
Copyright © American Academy of Addiction Psychiatry
The American Journal on Addictions
Volume 21, Issue 5, pages 411–415, September/October 2012
How to Cite
Smelson, D., Yu, L., Buyske, S., Gonzalez, G., Tischfield, J., Deutsch, C. K. and Ziedonis, D. (2012), Genetic Association of GABA-A Receptor Alpha-2 and Mu Opioid Receptor with Cocaine Cue-Reactivity: Evidence for Inhibitory Synaptic Neurotransmission Involvement in Cocaine Dependence. The American Journal on Addictions, 21: 411–415. doi: 10.1111/j.1521-0391.2012.00253.x
- Issue published online: 10 AUG 2012
- Article first published online: 10 AUG 2012
- Received May 10, 2011; revised May 27, 2011; accepted July 11, 2011.
Background: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving.
Methods: Thirty-four African American, cocaine-depend- ent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive.
Results: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= .001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p= .03).
Conclusions: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research. (Am J Addict 2012;21:411–415)