Eradication of Helicobacter pylori Infection Equally Improves Chronic Urticaria With Positive and Negative Autologous Serum Skin Test
Version of Record online: 21 AUG 2007
Volume 12, Issue 5, pages 567–571, October 2007
How to Cite
Magen, E., Mishal, J., Schlesinger, M. and Scharf, S. (2007), Eradication of Helicobacter pylori Infection Equally Improves Chronic Urticaria With Positive and Negative Autologous Serum Skin Test. Helicobacter, 12: 567–571. doi: 10.1111/j.1523-5378.2007.00522.x
- Issue online: 21 AUG 2007
- Version of Record online: 21 AUG 2007
- Helicobacter pylori;
Background: The aim of the study was to examine effects of Helicobacter pylori eradication on chronic idiopathic urticaria (CU) with and without positive aulogous serum skin test (ASST).
Methods: Seventy-eight patients with CU were checked for the positivity ASST and H. pylori urea 13C-urea breath test (13C-UBT). Twenty-one patients were with both positive ASST and positive 13C-UBT (group A), and 24 patients were with negative ASST and positive 13C-UBT (group B). All patients with positive 13C-UBT received a 14-day, open treatment with amoxicillin 1 g b.i.d., clarithromycin 500 mg b.i.d., and omeprazole 20 mg b.i.d. H. pylori eradication was assessed by a second 13C-UBT after 8 weeks. In control group, 33 patients with CU were included. The effect of H. pylori eradication on CU was evaluated by urticaria activity score (UAS), measured at study entry and at 8 and 16 weeks.
Results: At week 8, baseline UAS reduced from 4.7 ± 1.1 to 2.4 ± 1.4 (p = .027) in group A and from 4.3 ± 1.5 to 2.3 ± 1.2 (p = .008) in group B, without statistically significant difference between the two groups. In control group and in six patients with H. pylori eradication failure, no changes of UAS were noted.
Conclusion: Eradication of H. pylori infection by triple therapy significantly and equally reduces UAS in CU patients with positive and negative ASST.