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Alignment of the penicillin-binding protein 1A (PBP-1A) sequence of the amoxicillin-sensitive Helicobacter pylori strain 26695 (indicated by HP0597_AMXS) and of the amoxicillin resistant Hardenberg strain [1] (indicated by HP0597_AMXR) with that of the amoxicillin-resistant Helicobacter hepaticus strain ATCC 51449 (indicated as HH0890). The alignments was made with the ClustalX2 program [2], and asterisks represent residues conserved in all sequences, colons represent conserved substitutions, and dots indicate semi-conserved substitutions. The residue listed in yellow background is the Ser414 residue, of which mutation to Arg414 (indicated in green background) has been described to mediate amoxicillin resistance in H. pylori [1,3]. Residues listed in black background are residues which are potentially associated with amoxicillin resistance in H. pylori [4].

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