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Background. The clinical presentation and character of giant lipomas create diagnostic problems because of their close relationship with other mesenchymal benign and malign tumors. It is therefore of primary importance for the clinician to be familiar with epidemiologic and anatomic attributes of these lesions.

Objective. To evaluate and compare epidemiologic and clinical characteristics of giant lipomas operated in our clinic.

Methods. Twelve giant lipomas and one giant liposarcoma are included in the study.

Results. There were seven females and six males. The patients ranged in age between 22 and 75. The tumor duration was between 2 months and 40 years. The smallest lipoma size was 10×5×3 cm, and the largest was 19×9×5 cm. Two of the lipomas were located intermuscular. Mild hematoma formation was observed in two patients. Histopathologic evaluation was done for all specimens, and one myxoid liposarcoma was encountered.

Conclusion. When dealing with giant lipomas, liposarcomas should always be included in the differential diagnosis.