Treatment of Lower Eyelid Fat Pads Using Phosphatidylcholine: Clinical Trial and Review
Version of Record online: 5 MAR 2004
Volume 30, Issue 3, pages 422–427, March 2004
How to Cite
Ablon, G. and Rotunda, A. M. (2004), Treatment of Lower Eyelid Fat Pads Using Phosphatidylcholine: Clinical Trial and Review. Dermatologic Surgery, 30: 422–427. doi: 10.1111/j.1524-4725.2004.30114.x
- Issue online: 5 MAR 2004
- Version of Record online: 5 MAR 2004
Background. Injectable phosphatidylcholine, a lecithin-derived phospholipid, has been previously demonstrated to improve the appearance of infraorbital fat pad herniation. Current use internationally has led to a significant interest in this novel substance.
Objective. To evaluate the efficacy and safety of injectable phosphatidylcholine, we conducted an open-label study for the treatment of infraorbital fat pad herniation.
Methods. Patients received 0.4-mL phosphatidylcholine (50 mg/mL) injections within infraorbital fat pads every 2 weeks. Patient and physician grading of fat herniation, side effects, digital photographs, and a follow-up questionnaire was recorded.
Results. Ten of the 13 enrolled patients had three to five treatments. Improvements in fat herniation were reported in 80% and 70% of patients as graded by the physician and patients, respectively. Sixty percent of patients assessed their improvement as equal or greater than 5 points (on a 10-point fat herniation scale); however, the physician judged 40% of patients improving to this degree. Little or no response was seen in three patients. Side effects included burning, erythema, and swelling at the injection site. At follow-up averaging 9 months, 50% of patients reported persistence of benefit, 20% experienced some fading, and 30% were the nonresponders.
Conclusions. Injectable phosphatidylcholine is a novel treatment for infraorbital fat herniation that may benefit some patients who are considering blepharoplasty. Larger studies evaluating long-term safety and efficacy of phosphatidylcholine for cosmetic purposes are warranted.