Hypertrophic Scars and Keloids—A Review of Their Pathophysiology, Risk Factors, and Therapeutic Management
Article first published online: 8 JAN 2009
© 2009 by the American Society for Dermatologic Surgery, Inc.
Volume 35, Issue 2, pages 171–181, February 2009
How to Cite
WOLFRAM, D., TZANKOV, A., PÜLZL, P. and PIZA-KATZER, H. (2009), Hypertrophic Scars and Keloids—A Review of Their Pathophysiology, Risk Factors, and Therapeutic Management. Dermatologic Surgery, 35: 171–181. doi: 10.1111/j.1524-4725.2008.34406.x
- Issue published online: 27 JAN 2009
- Article first published online: 8 JAN 2009
BACKGROUND Hypertrophic scars and keloids result from an abnormal fibrous wound healing process in which tissue repair and regeneration-regulating mechanism control is lost. These abnormal fibrous growths present a major therapeutic dilemma and challenge to the plastic surgeon because they are disfiguring and frequently recur.
OBJECTIVE To provide updated clinical and experimental information on hypertrophic scars and keloids so that physicians can better understand and properly treat such lesions.
METHODS A Medline literature search was performed for relevant publications and for diverse strategies for management of hypertrophic scars and keloids.
CONCLUSION The growing understanding of the molecular processes of normal and abnormal wound healing is promising for discovery of novel approaches for the management of hypertrophic scars and keloids. Although optimal treatment of these lesions remains undefined, successful healing can be achieved only with combined multidisciplinary therapeutic regimens.