Differential Long-Term Stimulation of Type I versus Type III Collagen After Infrared Irradiation
Article first published online: 28 APR 2009
© 2009 by the American Society for Dermatologic Surgery, Inc.
Volume 35, Issue 7, pages 1099–1104, July 2009
How to Cite
TANAKA, Y., MATSUO, K., YUZURIHA, S. and SHINOHARA, H. (2009), Differential Long-Term Stimulation of Type I versus Type III Collagen After Infrared Irradiation. Dermatologic Surgery, 35: 1099–1104. doi: 10.1111/j.1524-4725.2009.01194.x
- Issue published online: 2 JUL 2009
- Article first published online: 28 APR 2009
BACKGROUND The dermis is composed primarily of type I (soft) and type III (rigid scar-like) collagen. Collagen degradation is considered the primary cause of skin aging. Studies have proved the efficacy of infrared irradiation on collagen stimulation but have not investigated the differential long-term effects of infrared irradiation on type I and type III collagen.
OBJECTIVE To determine differential long-term stimulation of type I and type III collagen after infrared (1,100–1,800 nm) irradiation.
METHODS AND MATERIALS In vivo rat tissue was irradiated using the infrared device. Histology samples were analyzed for type I and III collagen stimulation, visual changes from baseline, and treatment safety up to 90 days post-treatment.
RESULTS Infrared irradiation provided long-term stimulation of type I collagen and temporary stimulation of type III collagen. Treatment also created long-term smoothing of the epidermis, with no observed complications.
CONCLUSIONS Infrared irradiation provides safe, consistent, long-term stimulation of type I collagen but only short-term stimulation in the more rigid type III collagen. This is preferential for cosmetic patients looking for improvement in laxity and wrinkles while seeking smoother, more youthful skin.