Differential Long-Term Stimulation of Type I versus Type III Collagen After Infrared Irradiation

Authors

  • YOHEI TANAKA MD,

    1. Department of Plastic and Reconstructive Surgery, School of Medicine, Shinshu University, Matsumoto, Japan
    2. Clinica Tanaka Plastic and Reconstructive Surgery and Anti-aging Center, Matsumoto, Japan
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  • KIYOSHI MATSUO MD, PHD,

    1. Department of Plastic and Reconstructive Surgery, School of Medicine, Shinshu University, Matsumoto, Japan
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  • SHUNSUKE YUZURIHA MD, PHD,

    1. Department of Plastic and Reconstructive Surgery, School of Medicine, Shinshu University, Matsumoto, Japan
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  • HIROSHI SHINOHARA MD, PHD

    1. Department of Plastic and Reconstructive Surgery, School of Medicine, Shinshu University, Matsumoto, Japan
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Address correspondence and reprint requests to: Yohei Tanaka, MD, Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Asahi3-1-1, 390-8621 Matsumoto, Nagano, Japan, or e-mail: info@clinicatanaka.jp

Abstract

BACKGROUND The dermis is composed primarily of type I (soft) and type III (rigid scar-like) collagen. Collagen degradation is considered the primary cause of skin aging. Studies have proved the efficacy of infrared irradiation on collagen stimulation but have not investigated the differential long-term effects of infrared irradiation on type I and type III collagen.

OBJECTIVE To determine differential long-term stimulation of type I and type III collagen after infrared (1,100–1,800 nm) irradiation.

METHODS AND MATERIALS In vivo rat tissue was irradiated using the infrared device. Histology samples were analyzed for type I and III collagen stimulation, visual changes from baseline, and treatment safety up to 90 days post-treatment.

RESULTS Infrared irradiation provided long-term stimulation of type I collagen and temporary stimulation of type III collagen. Treatment also created long-term smoothing of the epidermis, with no observed complications.

CONCLUSIONS Infrared irradiation provides safe, consistent, long-term stimulation of type I collagen but only short-term stimulation in the more rigid type III collagen. This is preferential for cosmetic patients looking for improvement in laxity and wrinkles while seeking smoother, more youthful skin.

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