Fractionated Carbon Dioxide Laser Treatment of Photoaging: Prospective Study in 45 Patients and Review of the Literature
Article first published online: 31 AUG 2011
© 2011 by the American Society for Dermatologic Surgery, Inc.
Volume 37, Issue 9, pages 1279–1290, September 2011
How to Cite
TIERNEY, E. P. and HANKE, C. W. (2011), Fractionated Carbon Dioxide Laser Treatment of Photoaging: Prospective Study in 45 Patients and Review of the Literature. Dermatologic Surgery, 37: 1279–1290. doi: 10.1111/j.1524-4725.2011.02082.x
- Issue published online: 31 AUG 2011
- Article first published online: 31 AUG 2011
BACKGROUND Ablative fractional photothermolysis (AFP) has been reported to be effective for photoaging.
OBJECTIVE To perform a clinical trial in 45 patients with moderate to severe skin photoaging to quantify improvement with AFP.
MATERIALS AND METHODS A prospective, single-blind study in 45 patients who presented for desired treatment of photoaging. Patients received a series of two to three treatments with AFP.
RESULTS Thirty-nine women (86.7%) and six men (13.3%) were enrolled. Patients received two or three treatment sessions (mean 2.4). There were no incidence of adverse events of scarring, prolonged erythema (lasting more than 7 days), postinflammatory hyper- or hypopigmentation, or infection in the 108 treatment sessions given during this study. Mean improvement was 48.5% (95% confidence interval (CI)=44.6–52.4%) for skin texture, 50.3% (95% CI=46.1–54.5%) for skin laxity, 53.9% (95% CI=49.5–58.5%) for dyschromia, and 52.4% (95% CI=47.9–56.9%) for overall cosmetic outcome (all p<.05).
CONCLUSIONS Significant improvement in photoaging of the face can be achieved using an AFP device with skin types I to III after a series of two to three treatments.
The authors have indicated no significant interest with commercial supporters.