Low-Fluence Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser for the Treatment of Facial Partial Unilateral Lentiginosis in Koreans


  • The authors have indicated no significant interest with commercial supporters.

Address correspondence and reprint requests to: Eung Ho Choi, Department of Dermatology, Yonsei University Wonju College of Medicine, 162 Ilsandong, Wonju, 220-701, Republic of Korea, or e-mail: choieh@yonsei.ac.kr



Established pigment lasers have been used in partial unilateral lentiginosis (PUL) have shown unsatisfactory results.


To determine the effectiveness and safety of low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser treatment of PUL in Koreans.

Materials and Methods

Ten Korean patients with facial PUL were treated with 1,064-nm QS Nd:YAG laser, 7-mm spot size, 1.5- to 2.5-J/cm2 fluence at 2-week intervals. Standard digital photographs were taken under the same condition at baseline and at each follow-up visit. Independent dermatologists evaluated the photographs. All patients completed a questionnaire to assess their subjective satisfaction with the laser treatment using a 5-point grading system. Degree of pain was assessed using a visual analog scale (0–10). Any complications and side effects were recorded at each visit. Patients were followed up every 4 weeks for 12 weeks after the last laser treatment.


Five of 10 patients (50%) had achieved excellent improvement (76–100%) at the end of treatment, and the remaining 50% had good improvement (51–75%). In patient self-evaluation of the degree of improvement of PUL, nine (90%) assessed it as very much to much improved (>50% improvement), and 1 (10%) assessed it as moderate (50–75%). Subjects rated the pain associated with laser treatment at a mean score of 3.3 (range: 1–5) on a scale of 1 to 10. Mottled hypopigmentation developed in two patients. At follow-up, 12 weeks after the last laser session, all of the patients had partial recurrence, which wqw resolved with one to two sessions of laser treatment.


Low-fluence 1,064-nm QS Nd:YAG laser treatment for facial PUL in Koreans showed improvement with no significant side effects. We recommend the low-fluence 1,064-nm QS Nd:YAG laser as a treatment option for facial PUL.