Dermalis, representatives of Anteis in Brazil, donated the products used in this study.
Rejuvenation of Periorbital Area: Treatment with an Injectable Nonanimal Non-Crosslinked Glycerol Added Hyaluronic Acid Preparation
Article first published online: 14 OCT 2011
© 2011 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.
Volume 38, Issue 2, pages 192–198, February 2012
How to Cite
Succi, I. B., Silva, R. T. d. and Orofino-Costa, R. (2012), Rejuvenation of Periorbital Area: Treatment with an Injectable Nonanimal Non-Crosslinked Glycerol Added Hyaluronic Acid Preparation. Dermatologic Surgery, 38: 192–198. doi: 10.1111/j.1524-4725.2011.02182.x
- Issue published online: 6 FEB 2012
- Article first published online: 14 OCT 2011
Therapeutic approaches to aging of the periorbital region are unique because of the delicacy of the anatomical structures and the possibility of adverse events. The synthesis of hyaluronic acid (HA) and other components responsible for skin hydration and elasticity diminish with age.
To evaluate the efficacy and safety of an injectable product containing non-crosslinked HA of nonanimal origin in association with glycerol to treat aging of the periorbital region.
Materials and Methods
A pilot study in which 20 women were administered three monthly superficial intradermal injections of non-crosslinked HA of nonanimal origin containing glycerol in the periorbital area. The clinical results consisted of the evaluation of three researchers and an independent evaluator and the degree of posttreatment patient satisfaction.
An improvement of between 25% and 50% in skin brightness, texture, and turgor was observed in the periorbital area. Papules were present after each application, and hematoma was the longest lasting effect. All adverse events were reversible and well tolerated.
Injections of HA of nonanimal origin, in association with glycerol, using a micropuncture technique are well tolerated and can improve skin brightness and turgor and reduce roughness in the periorbital region.