Pleomorphic Adenoma of the Breast Should Be Excised with a Cuff of Normal Tissue


Address correspondence and reprint requests to: Mr. Biku J. John, Department of Surgery, Mayday University Hospital, Croydon CR7 7YE, United Kingdom, or e-mail:


Abstract:  Pleomorphic adenoma is a benign tumor found rarely in the breast but commonly in the salivary gland. Unlike the salivary gland variant management guidelines are poorly defined in the breast. We describe the first case of pleomorphic adenoma of the breast that has recurred for the second time following previous surgical excisions, and review the available literature. Due to the risk of recurrence and malignant transformation, we recommend complete excision of the lesion with a cuff of normal tissue, as is the practice in the salivary gland. Clinicians should be aware of the condition, as preoperative diagnosis will facilitate adequate surgery. Patients should be informed about the risk of recurrence. We recommend follow-up for at least a period of 5 years with yearly clinical examinations.