Acinar Pattern of Mammary Paget’s Disease: A Case Report

Authors


Address correspondence and reprint request to: Dr. Penny J. Barnes, Anatomical Pathology, Pathology and Laboratory Medicine, 7th Floor Mackenzie Building, QEII HSC (VG Site), 5788 University Avenue, Halifax, NS, Canada B3H 1V8, or e-mail: Penny.Barnes@cdha.nshealth.ca.

Abstract

Abstract:  Mammary Paget’s disease (MPD) is an uncommon in situ neoplasm of the nipple-areolar complex and surrounding skin. It is almost always associated with mammary ductal carcinoma in situ (DCIS), high-grade or invasive carcinoma, usually of ductal origin. MPD has only rarely been described in association with specialized forms of breast carcinoma. We report an unusual case of an acinar pattern of MPD with low-grade cytological atypia, associated with invasive papillary carcinoma and micropapillary DCIS of the lactiferous ducts, in an 83-year-old woman. Most cases of MPD are characterized by intraepidermal spread of discohesive glandular epithelial cells with high-grade nuclear atypia. A predominant acinar pattern of MPD is extremely uncommon and, to our knowledge, has not been formally reported. The histological features and differential diagnosis are discussed.

Ancillary