Presence of a Micropapillary Pattern in Mucinous Carcinomas of the Breast and its Impact on the Clinical Behavior
Article first published online: 30 JUL 2008
© 2008 Wiley Periodicals, Inc.
The Breast Journal
Volume 14, Issue 5, pages 412–420, September/October 2008
How to Cite
Shet, T. and Chinoy, R. (2008), Presence of a Micropapillary Pattern in Mucinous Carcinomas of the Breast and its Impact on the Clinical Behavior. The Breast Journal, 14: 412–420. doi: 10.1111/j.1524-4741.2008.00616.x
- Issue published online: 5 SEP 2008
- Article first published online: 30 JUL 2008
- colloid carcinoma;
- micropapillary carcinoma;
- mucinous carcinoma
Abstract: Infiltrating micropapillary carcinomas (IMPC) of breast are highly angioinvasive tumors with poor prognosis. This study is based on the observation that a similar micropapillary pattern is also observed in mucinous carcinomas of breast. About 102 mucinous carcinomas were evaluated for the presence and impact of this micropapillary pattern on the clinical behavior. Of these, 68 were mucinous carcinomas with a micropapillary pattern (MUMPC), 20 had MUMPC mixed with an infiltrating duct carcinoma component, two were solid variants of papillary carcinoma with mucin (SVPCMU), five had collision of the MUMPC and SVPCMU patterns and seven were mucinous carcinomas with signet ring cells (MUS). The factors negatively affecting overall survival (OAS) and disease-free survival (DFS) included the histological type of mucinous carcinoma, nodal metastases, an irregular tumor border, <50% mucin and an IMPC type of local recurrence or metastases. In the multivariate analysis, the histologic type of mucinous carcinoma and an irregular tumor border were most significant for OAS and DFS. Thus, 86% of mucinous carcinomas in this study were mucinous variants of the angioinvasive infiltrating micropapillary carcinomas. These tumors can produce IMPC type of metastases and thus should be treated aggressively.