Lobular Neoplasia of the Breast
Article first published online: 4 AUG 2010
© 2010 Wiley Periodicals, Inc.
The Breast Journal
Volume 16, Issue 5, pages 519–528, September/October 2010
How to Cite
Venkitaraman, R. (2010), Lobular Neoplasia of the Breast. The Breast Journal, 16: 519–528. doi: 10.1111/j.1524-4741.2010.00971.x
- Issue published online: 6 SEP 2010
- Article first published online: 4 AUG 2010
- atypical lobular hyperplasia;
- lobular carcinoma in situ;
- lobular neoplasia
Abstract: Lobular neoplasia is increasingly being detected, probably due to the widespread screening for breast malignancies. The understanding of lobular neoplasia is undergoing a paradigm shift, from being considered a predictor of recurrence to being considered a pre-invasive lesion, based on molecular studies suggesting a clonal link with invasive lobular cancer. The management of patients diagnosed to have lobular neoplasia is in evolution, with the increasing need for risk stratification and hence the necessity to identify this entity separately as either lobular carcinoma in-situ and atypical lobular hyperplasia. The indications for wide local excision for patients diagnosed to have lobular neoplasia on biopsy are being defined. The evidence for preventive strategies like hormonal treatment with Tamoxifen or aromatase inhibitors for high risk patients is increasing, with the results from prospective interventional trials. The role of screening magnetic resonance imaging for surveillance of high risk patients with lobular neoplasia is under evaluation.