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The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing


Reprint requests Mr. Kevin Conway, Wound Healing Research Unit, Cardiff Medicentre, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4UJ,
United Kingdom.
Fax: +29 2075 4217;


Wound healing involves a number of cellular and molecular events, many of which are controlled by soluble growth factors. In the process of healing, hepatocyte growth factor, a cytokine known to act as mitogen, motogen, and morphogen, has been postulated to play multiple roles during several stages of this complex biological process. Produced primarily by stromal fibroblasts, hepatocyte growth factor regulates angiogenesis, vascular permeability, cell migration, matrix deposition and degradation, and other biological processes. The current article discusses recent progress in understanding the multiple roles played by this growth factor in tissue repair.