Translational systems biology of inflammation and healing

Authors

  • Yoram Vodovotz PhD

    1. Department of Surgery; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • This material was presented as part of the Keynote Address given by Dr. Vodovotz at the 2008 Annual Meeting of the Wound Healing Society, Symposium for Advanced Wound Care-Wound Healing Society Joint Meeting, San Diego, CA, April 24–27, 2008.

Reprint requests:
Yoram Vodovotz, PhD, Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA 15213. Tel: +1 412 647 5609;
Fax: +1 412 383 5946;
Email: vodovotzy@upmc.edu

ABSTRACT

Personalized medicine is a major goal for the future of healthcare, and we suggest that computational simulations are necessary in order to achieve it. Inflammatory diseases, both acute and chronic, represent an area in which personalized medicine is especially needed, given the high level of individual variability that characterizes these diseases. We have created such simulations, and have used them to gain basic insights into the inflammatory response under baseline, gene-knockout, and drug-treated experimental animals; for in silico experiments and clinical trials in sepsis, trauma, and wound healing; and to create patient-specific simulations in polytrauma, traumatic brain injury, and vocal fold inflammation. Since they include both circulating and tissue-level inflammatory mediators, these simulations transcend typical cytokine networks by associating inflammatory processes with tissue/organ damage via tissue damage/dysfunction. We suggest that computational simulations are the cornerstone of Translational Systems Biology approaches for inflammatory diseases.

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