The Natural Treatment of Hypertension

Authors

  • Amanda James Wilburn PharmD,

    1. From the University of Mississippi School of Pharmacy, University, MS;1 and the Departments of Pharmacy Practice,2Internal Medicine,3 and Pharmacology and Toxicology,4 University of Mississippi Medical Center School of Medicine, Jackson, MS
    Search for more papers by this author
  • 1 Deborah S. King PharmD,

    1. From the University of Mississippi School of Pharmacy, University, MS;1 and the Departments of Pharmacy Practice,2Internal Medicine,3 and Pharmacology and Toxicology,4 University of Mississippi Medical Center School of Medicine, Jackson, MS
    Search for more papers by this author
  • 1 2 3 James Glisson MD, PharmD,

    1. From the University of Mississippi School of Pharmacy, University, MS;1 and the Departments of Pharmacy Practice,2Internal Medicine,3 and Pharmacology and Toxicology,4 University of Mississippi Medical Center School of Medicine, Jackson, MS
    Search for more papers by this author
  • 3 Robin W. Rockhold PhD,

    1. From the University of Mississippi School of Pharmacy, University, MS;1 and the Departments of Pharmacy Practice,2Internal Medicine,3 and Pharmacology and Toxicology,4 University of Mississippi Medical Center School of Medicine, Jackson, MS
    Search for more papers by this author
  • and 4 Marion R. Wofford MD, MPH 3

    1. From the University of Mississippi School of Pharmacy, University, MS;1 and the Departments of Pharmacy Practice,2Internal Medicine,3 and Pharmacology and Toxicology,4 University of Mississippi Medical Center School of Medicine, Jackson, MS
    Search for more papers by this author

Marion Wofford, MD, MPH, University of Mississippi Medical Center, Division of Hypertension, 2500 North State Street, Jackson, MS 39216 E-mail: mwofford@medicine.umsmed.edu

Abstract

The goal of this review is to evaluate the efficacy of commonly available dietary supplements in the treatment of hypertension, using the average blood pressure reduction achieved with the implementation of lifestyle modifications as a standard. For this reason, the authors focus on the antihypertensive potential of these agents rather than pharmacology, pharmacokinetics, adverse effects, or supplement-drug interactions. For the purpose of this review, dietary supplements are defined as exhibiting some evidence of benefit if a systolic blood pressure reduction of 9.0 mm Hg or greater and/or a diastolic blood pressure reduction of 5.0 mm Hg or greater has been observed in previously published, peer-reviewed trials. These defining limits are based on the average blood pressure reduction associated with the implementation of certain lifestyle modifications. Agents with some evidence of benefit include coenzyme Q10, fish oil, garlic, vitamin C, and L-arginine.

Ancillary