Serum Uric Acid as a Risk Factor for Cardiovascular and Renal Disease: An Old Controversy Revived

Authors

  • Francesca Viazzi MD,

    1. From the Department of Internal Medicine, University of Genoa, Genoa, Italy, and the Department of Cardionephrology, Azienda Ospedaliera San Martino, Genoa, Italy
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  • Giovanna Leoncini MD,

    1. From the Department of Internal Medicine, University of Genoa, Genoa, Italy, and the Department of Cardionephrology, Azienda Ospedaliera San Martino, Genoa, Italy
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  • Elena Ratto MD,

    1. From the Department of Internal Medicine, University of Genoa, Genoa, Italy, and the Department of Cardionephrology, Azienda Ospedaliera San Martino, Genoa, Italy
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  • Roberto Pontremoli MD, PhD

    1. From the Department of Internal Medicine, University of Genoa, Genoa, Italy, and the Department of Cardionephrology, Azienda Ospedaliera San Martino, Genoa, Italy
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Francesca Viazzi, MD, Department of Internal Medicine, University of Genoa and Department of Cardionephrology, Azienda Ospedaliera San Martino, Viale Benedetto XV, 6 - 16132 Genoa, Italy
E-mail: francesca.viazzi@unige.it

Abstract

Hyperuricemia is commonly associated with traditional risk factors such as abnormalities in glucose metabolism, dyslipidemia, and hypertension. Recent studies have revived the controversy over the role of serum uric acid as an independent prognostic factor for cardiovascular mortality. The authors review clinical and experimental evidence concerning the role of serum uric acid in the development of cardiovascular and renal damage. Results of trials suggesting that serum uric acid variations over time may have a prognostic impact are also discussed.

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