The presence of orthostatic hypotension has been shown to be a significant, independent predictor of all-cause mortality. Systolic and diastolic orthostatic hypotension, reversal of the circadian pattern, and postprandial hypotension are some of the hemodynamic factors that may contribute to the increased mortality seen in patients with orthostatic hypotension. The high variability of blood pressure in orthostatic hypotension cannot usually be adequately assessed by a one-time measurement. In this group of patients, 24-hour ambulatory blood pressure monitoring may be more useful.