To whom requests for reprints should be addressed at Laboratory of Molecular Endocrinology, CHUL Research Center, 2705, boul.Laurier, Québec, Canada G1V 4G2. E-mail: Serge.Rivest@crchul.ULaval.Ca
How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli
Article first published online: 18 JUL 2008
Proceedings of the Society for Experimental Biology and Medicine
Volume 223, Issue 1, pages 22–38, January 2000
How to Cite
Rivest, S., Lacroix, S., Vallières, L., Nadeau, S., Zhang, J. and Laflamme, N. (2000), How the Blood Talks to the Brain Parenchyma and the Paraventricular Nucleus of the Hypothalamus During Systemic Inflammatory and Infectious Stimuli . Proceedings of the Society for Experimental Biology and Medicine, 223: 22–38. doi: 10.1111/j.1525-1373.2000.22304.x
Our work on this subject is currently supported by the Medical Research Council (MRC) of Canada. Serge Rivest is a Canadian MRC Scientist. Ji Zhang and Sylvain Nadeau are supported by Ph.D. studentships from the Canadian MRC, whereas Steve Lacroix and Luc Vallières were supported by Ph.D. studentships from the Natural Sciences and Engineering Research Council of Canada and the Fonds pour la Formation des Chercheurs et l'Aide à la Recherche du Québec (L.V.). Drs. Vallières and Lacroix are presently MRC postdoc fellows at the Salk Institute and UCSD in La Jolla, California, respectively.
- Issue published online: 18 JUL 2008
- Article first published online: 18 JUL 2008
Abstract. There are exciting new developments regarding the molecular mechanisms involved in the influence of circulating proinflammatory molecules within cells of the blood-brain barrier (BBB) during systemic immune challenges. These molecules, when present in the circulation, have the ability to trigger a series of events in cascade, leading to either the mitogen-activated protein (MAP) kinases/nuclear factor kappa B (NF-κB) or the janus kinase (JAK)/signal transducer and activator of transcription (STAT) transduction pathways in vascular-associated cells of the central nervous system (CNS). The brain blood vessels exhibit both constitutive and induced expression of receptors for different proinflammatory ligands that have the ability to stimulate these signaling molecules. Depending on the challenges and the cytokines involved, the transduction signal(s) solicited in cells of the BBB may orient the neuronal activity in a very specific manner in activating the transcription and production of soluble factors, such as prostaglandins (PGs). It is interesting to note that cytokines as well as systemic localized inflammation stimulate the cells of the BBB in a nonselective manner (i.e., within both large blood vessels and small capillaries across the brain). This nonselectivity raises several questions with regard to the localized neuronal activation induced by different experimental models of inflammation and cytokines. It is possible that the selectivity of the neuronal response is a consequence of the fine interaction between nonparenchymal synthesis of soluble mediators and expression of specific receptors for these ligands within parenchymal elements of different brain nuclei. This review will present the recent developments on this concept and the mechanisms that take place in cells of the BBB, which lead to the neuronal circuits involved in restoring the body's homeostasis during systemic immunogenic challenges. The induction of fever, the hypothalamic-pituitary adrenal (HPA) axis, and other autonomic functions are among the physiological outcomes necessary for the protection of the mammalian organism in the presence of foreign material.