Basic Science and Dialysis
Genetic Causation of Neointimal Hyperplasia in Hemodialysis Vascular Access Dysfunction
Article first published online: 15 SEP 2011
© 2011 Wiley Periodicals, Inc.
Seminars in Dialysis
Volume 25, Issue 1, pages 65–73, January/February 2012
How to Cite
Lee, T. and Wadehra, D. (2012), Genetic Causation of Neointimal Hyperplasia in Hemodialysis Vascular Access Dysfunction. Seminars in Dialysis, 25: 65–73. doi: 10.1111/j.1525-139X.2011.00967.x
- Issue published online: 24 JAN 2012
- Article first published online: 15 SEP 2011
The major cause of hemodialysis vascular access failure is venous stenosis resulting from neointimal hyperplasia. Genetic factors have been shown to be associated with cardiovascular disease and peripheral vascular disease (PVD) in the general population. Genetic factors may also play an important role in vascular access stenosis and development of neointimal hyperplasia by affecting pathways that lead to inflammation, endothelial function, oxidative stress, and vascular smooth muscle proliferation. This review will discuss the role of genetics in understanding neointimal hyperplasia development in hemodialysis vascular access dysfunction and other disease processes with similar neointimal hyperplasia development such as coronary artery disease and PVD.