Implications of the Frequent Hemodialysis Network-Daily Trial

Authors

  • Kalani L. Raphael,

    1. Division of Nephrology & Hypertension, University of Utah and Salt Lake City Veterans Affairs Health Care System, Salt Lake City, Utah
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  • Alfred K. Cheung

    1. Division of Nephrology & Hypertension, University of Utah and Salt Lake City Veterans Affairs Health Care System, Salt Lake City, Utah
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Address correspondence to: Alfred K. Cheung, M.D., 85 N. Medical Dr. East, Room 201, Salt Lake City, UT 84112, Tel.: (801) 585-5215, Fax: (801) 581-8934, or e-mail: alfred.cheung@hsc.utah.edu.

Abstract

Despite many years of experience with hemodialysis, the outcomes of maintenance dialysis patients remain poor. The Frequent Hemodialysis Network-Daily (FHN-Daily) Trial found that six times per week in-center short hemodialysis decreased left ventricular mass and improved self-reported physical functioning over a 1-year intervention period compared with conventional thrice-weekly dialysis. Despite the promising results, caution is needed in the projection of these intermediate outcomes to hard clinical endpoints, such as cardiovascular events and death.

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