Diastolic Heart Failure in Dialysis Patients: Mechanisms, Diagnostic Approach, and Treatment
Article first published online: 24 JAN 2012
© 2012 Wiley Periodicals, Inc.
Seminars in Dialysis
Volume 25, Issue 1, pages 35–41, January/February 2012
How to Cite
Pecoits-Filho, R., Bucharles, S. and Barberato, S. H. (2012), Diastolic Heart Failure in Dialysis Patients: Mechanisms, Diagnostic Approach, and Treatment. Seminars in Dialysis, 25: 35–41. doi: 10.1111/j.1525-139X.2011.01011.x
- Issue published online: 24 JAN 2012
- Article first published online: 24 JAN 2012
Heart failure (HF) is very common in the general population, and risk factors for HF, such as coronary artery disease, diabetes, obesity, and hypertension, are frequently present in patients with CKD. Therefore, HF is also an important cause of morbidity and mortality in this population. Diastolic heart failure (DHF), also called HF with preserved ejection fraction, refers to a clinical syndrome in which patients have symptoms and signs of HF, normal or near normal left ventricular (LV) systolic function, and evidence of diastolic dysfunction (e.g., abnormal LV filling and elevated filling pressure). Recent data suggest that HF with normal ejection fraction is even more common in patients than HF with low ejection fraction, including those on hemodialysis. Not surprisingly, DHF is a strong predictor of death in CKD patients. In this article, we review the information available on the mechanisms, clinical presentation, impact, and potential interventions in DHF based on evidence from CKD patients, as well as evidence from the general population potentially applicable to the CKD population.