Are there Neurological Consequences of Recurrent Intradialytic Hypotension?
Version of Record online: 22 FEB 2012
© 2012 Wiley Periodicals, Inc.
Seminars in Dialysis
Volume 25, Issue 3, pages 253–256, May/June 2012
How to Cite
Eldehni, M. T. and McIntyre, C. W. (2012), Are there Neurological Consequences of Recurrent Intradialytic Hypotension?. Seminars in Dialysis, 25: 253–256. doi: 10.1111/j.1525-139X.2012.01057.x
- Issue online: 20 MAY 2012
- Version of Record online: 22 FEB 2012
Structural abnormalities of the brain are common in hemodialysis (HD) patients, as are a wide range of severe functional deficiencies of cerebral function. Both depression and increasing dependency are highly prevalent in HD patients and worsen severely within the first 12 months of dialysis initiation. HD, as it is commonly practiced, is associated with significant recurrent episodes of circulatory stress. This results in acute injury to the heart, skin, kidney and gut, and drives longer term end-organ chronic injury. This article aims to explore the hypothesis that the cerebral microcirculation is also sensitive to dialysis-based circulatory stress (and other multiorgan consequences of recurrent dialysis-induced ischemia), and that this may drive specific patterns of brain injury with resultant psychiatric and functional consequences.