Timmy Lee and Nida Safdar contributed equally to this manuscript.
Preexisting Venous Calcification Prior to Dialysis Vascular Access Surgery
Article first published online: 27 MAR 2012
© 2012 Wiley Periodicals, Inc.
Seminars in Dialysis
Volume 25, Issue 5, pages 592–595, September/October 2012
How to Cite
Lee, T., Safdar, N., Mistry, M. J., Wang, Y., Chauhan, V., Campos, B., Munda, R., Cornea, V. and Roy-Chaudhury, P. (2012), Preexisting Venous Calcification Prior to Dialysis Vascular Access Surgery. Seminars in Dialysis, 25: 592–595. doi: 10.1111/j.1525-139X.2012.01063.x
- Issue published online: 20 SEP 2012
- Article first published online: 27 MAR 2012
Vascular calcification is present in arterial vessels used for dialysis vascular access creation prior to surgical creation. Calcification in the veins used to create a new vascular access has not previously been documented. The objective of this study was to describe the prevalence of venous calcification in samples collected at the time of vascular access creation. Sixty-seven vein samples were studied. A von Kossa stain was performed to quantify calcification. A semi-quantitative scoring system from 0 to 4+ was used to quantify the percentage positive area for calcification as a fraction of total area (0: 0; 1+: 1–10%; 2+: 11–25%; 3+: 26–50%; 4+: >50% positive). Twenty-two of 67 (33%) samples showed evidence of venous calcification. Histologic examination showed varying degrees of calcification within each cell layer. Among the subset of patients with calcification, 4/22 (18%), 19/22 (86%), 22/22 (100%), and 7/22 (32%) had calcification present within the endothelium, intima, media, and adventitia, respectively. The mean semi-quantitative scores of the 22 samples with calcification were 0.18 ± 0.08, 1.2 ± 0.14, 1.6 ± 0.13, and 0.36 ± 0.12 for the endothelium, intima, media, and adventitia, respectively. Our results demonstrate that vascular calcification is present within veins used to create new dialysis vascular access, and located predominately within the neointimal and medial layers.