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Arterial Micro-Calcification of Vascular Access is Associated with Aortic Arch Calcification and Arterial Stiffness in Hemodialysis Patients

  1. Hyun Gyung Kim1,
  2. Sun Cheol Park2,
  3. Soo Lim Lee3,
  4. Ok-Ran Shin4,
  5. Sun Ae Yoon1,
  6. Chul Woo Yang1,
  7. Yongsoo Kim1,
  8. Young Ok Kim1

Article first published online: 22 AUG 2012

DOI: 10.1111/j.1525-139X.2012.01113.x

Issue

Seminars in Dialysis

Seminars in Dialysis

Volume 26, Issue 2, pages 216–222, March/April 2013

Additional Information

How to Cite

Kim, H. G., Park, S. C., Lee, S. L., Shin, O.-R., Yoon, S. A., Yang, C. W., Kim, Y. and Kim, Y. O. (2013), Arterial Micro-Calcification of Vascular Access is Associated with Aortic Arch Calcification and Arterial Stiffness in Hemodialysis Patients. Seminars in Dialysis, 26: 216–222. doi: 10.1111/j.1525-139X.2012.01113.x

Author Information

  1. 1

    Division of Nephrology, Department of Internal Medicine

  2. 2

    Department of Vascular Surgery

  3. 3

    Department of Radiology

  4. 4

    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea

*Address correspondence to: Young Ok Kim, MD, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea Medical College, 65-1, Geumo-dong, Uijeongbu-city, Gyeonggi-do, Korea, e-mail: cmckyo@catholic.ac.kr

Publication History

  1. Issue published online: 21 MAR 2013
  2. Article first published online: 22 AUG 2012

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Abstract

Vascular calcification of the coronary arteries or aorta is an independent risk factor for cardiovascular outcome, but clinical significance of arterial micro-calcification (AMC) of vascular access is unclear in hemodialysis (HD) patients. Sixty-five patients awaiting vascular access operation were enrolled. We compared surrogate markers of cardiovascular morbidity such as aortic arch calcification (AoAC) by chest radiography, arterial stiffness by brachial-ankle pulse wave velocity (baPWV) and endothelial dysfunction by flow-mediated dilatation (FMD) between patients with and without AMC of vascular access on von Kossa staining. AMC of vascular access was detected in 36 (55.4%). The AMC-positive group had significantly higher incidence of AoAC (63.9% vs. 20.7%, p < 0.001) and higher baPWV (26.5 ± 9.4 m/s vs. 19.8 ± 6.6 m/s, p = 0.006) than the AMC-negative group. There was no significant difference in FMD between the two groups (5.4 ± 2.6% vs. 5.7 ± 3.5%, p = 0.764). The AMC-positive group had higher incidence of diabetes mellitus, higher systolic blood pressure and wider pulse pressure than the AMC-negative group. This study suggests that AMC of vascular access may be associated with cardiovascular morbidity via AoAC and arterial stiffness in HD patients.

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