For more information on author guidelines, an explanation of our peer review process, and conflict of interest informed consent policies, please go to http://www.wiley.com/bw/submit.asp?ref=1094-7159&site=1
Prospective Nonrandomized Trial
Long-Term Outcome in Occipital Nerve Stimulation Patients With Medically Intractable Primary Headache Disorders
Article first published online: 6 AUG 2012
© 2012 International Neuromodulation Society
Neuromodulation: Technology at the Neural Interface
Volume 16, Issue 6, pages 557–564, November/December 2013
How to Cite
Brewer, A. C., Trentman, T. L., Ivancic, M. G., Vargas, B. B., Rebecca, A. M., Zimmerman, R. S., Rosenfeld, D. M. and Dodick, D. W. (2013), Long-Term Outcome in Occipital Nerve Stimulation Patients With Medically Intractable Primary Headache Disorders. Neuromodulation: Technology at the Neural Interface, 16: 557–564. doi: 10.1111/j.1525-1403.2012.00490.x
Source(s) of financial support: None.
As noted in the manuscript, some of the patients described in this work were included in a previous study of long-term ONS outcome. Schwedt et al., Cephalalgia 2007.
Reprints will not be available from the author.
Conflict of Interest: Within the past three years, Drs. Trentman, Zimmerman, Dodick, and Vargas have received research support from St Jude-Neuromodulation and Medtronic, Inc. Dr. Dodick has provided consulting services within the past three years for Medtronic, Inc. and Boston Scientific Corporation. In the remote past (greater than three years), Drs. Trentman and Zimmerman provided consulting services for Advanced Bionics Corporation, now Boston Scientific Neuromodulation.
- Issue published online: 15 JAN 2014
- Article first published online: 6 AUG 2012
- Received: April 12, 2012 Revised: June 15, 2012 Accepted: June 27, 2012
- Cluster headache;
- occipital nerve stimulation;
- peripheral nerve stimulation
Introduction: Occipital nerve stimulation (ONS) may provide relief for refractory headache disorders. However, scant data exist regarding long-term ONS outcomes.
Methods: The methods used were retrospective review of the medical records of all (nonindustry study) patients who were trialed and implanted with occipital nerve stimulator systems at our institution, followed by a phone interview. Up to three attempts were made to contact each patient, and those who were contacted were given the opportunity to participate in a brief phone interview regarding their ONS experience. Data for analysis were gleaned from both the phone interview and the patient's medical records.
Results: Twenty-nine patients underwent a trial of ONS during the 8.5-year study period. Three patients did not go on to permanent implant, 12 could not be contacted, and 14 participated in the phone interview. Based upon the phone interview (if the patient was contacted) or chart review, ONS was deemed successful in five of the 12 migraine, four of the five cluster headache, and five of the eight miscellaneous headache patients, and therapy was documented as long as 102 months. In one of the 26 patients, success of ONS could not be determined. Among patients deemed to have successful outcomes, headache frequency decreased by 18%, severity by 27%, and migraine disability score by 50%. Fifty-eight percent of patients required at least one lead revision.
Discussion: These results, although limited by their retrospective nature, suggest that ONS can be effective long term despite technical challenges. The number of patients within each headache subtype was insufficient to draw conclusions regarding the differential effect of ONS.
Conclusions: Randomized controlled long-term studies in specific, intractable, primary headache disorders are indicated.