Conflict of Interest: The authors reported no conflict of interest.
Editor’s Choice: Prospective Nonrandomized Trial
F-Wave Suppression Induced by Suprathreshold High-Frequency Repetitive Trascranial Magnetic Stimulation in Poststroke Patients with Increased Spasticity
Article first published online: 24 OCT 2012
© 2012 International Neuromodulation Society
Neuromodulation: Technology at the Neural Interface
Volume 16, Issue 3, pages 206–211, May/June 2013
How to Cite
F-Wave Suppression Induced by Suprathreshold High-Frequency Repetitive Trascranial Magnetic Stimulation in Poststroke Patients with Increased Spasticity. Neuromodulation 2012; e-pub ahead of print. DOI: 10.1111/j.1525-1403.2012.00520.x, , , , , , , ,
For more information on author guidelines, an explanation of our peer review process, and conflict of interest informed consent policies, please go to http://www.wiley.com/bw/submit.asp?ref=1094-7159&site=1
- Issue published online: 4 JUN 2013
- Article first published online: 24 OCT 2012
- Manuscript Accepted: 6 SEP 2012
- Manuscript Revised: 27 JUN 2012
- Manuscript Received: 31 JAN 2012
- Ministry of Education, Culture, Sports, Science and Technology of Japan. Grant Number: C-18591614
- repetitive transcranial magnetic stimulation (rTMS);
- spinal cord excitability
High-intensity and high-frequency repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex was carried out in poststroke patients with increased spasticity, and the changes in F-wave parameters in comparison with M-wave parameters induced by rTMS were examined.
Ten-hertz rTMS pulses were delivered to the primary motor cortex of the lesion side at 110% intensity of the resting motor threshold, and F-waves were obtained from the first dorsal interosseous muscle. F-waves were recorded before (pre-stim) and immediately after the end of rTMS (post-stim) in poststroke patients.
F-wave persistence and F/M Amp.Ratio increased significantly in patients with lesions in upper motor tract as compared with healthy subjects (Wilcoxon rank sum test, p = 0.00023 and p = 0.0073, respectively). After the rTMS application, both F-wave persistence and F/M Amp.Ratio decreased significantly (paired t-test, p = 0.0095 and p = 0.037, respectively). However, the F-wave amplitude did not show a statistically significant variance in poststroke patients.
High-frequency suprathreshold rTMS may suppress the F-waves by enhancing the inhibitory effect on spinal excitability through the corticospinal tract, and F-wave persistence and F/M Amp.Ratio can be used to determine the effect of rTMS on patients with increased spasticity.