Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk
Article first published online: 17 MAR 2010
© 2010 Wiley Periodicals, Inc.
Evolution & Development
Volume 12, Issue 2, pages 131–143, March/April 2010
How to Cite
Hsia, C. C., Paré, A. C., Hannon, M., Ronshaugen, M. and McGinnis, W. (2010), Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk. Evolution & Development, 12: 131–143. doi: 10.1111/j.1525-142X.2010.00399.x
- Issue published online: 17 MAR 2010
- Article first published online: 17 MAR 2010
SUMMARY We tested whether Artemia abd-A could repress limbs in Drosophila embryos, and found that although abd-A transcripts were produced, ABD-A protein was not. Similarly, developing Artemia epidermal cells showed expression of abd-A transcripts without accumulation of ABD-A protein. This finding in Artemia reveals a new variation in Hox gene function that is associated with morphological evolution. In this case, a HOX protein expression pattern is completely absent during early development, although the HOX protein is expressed at later stages in the central nervous system in a “homeotic-like” pattern. The combination of an absence of ABD-A protein expression in the Artemia limb primordia and the weak repressive function of Artemia UBX protein on the limb-promoting gene Dll are likely to be two reasons why homonomous limbs develop throughout the entire Artemia trunk.