Get access

Outcome of patients with early ovarian cancer undergoing three courses of adjuvant chemotherapy following complete surgical staging

Authors

  • M. SHIMADA,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • J. KIGAWA,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • Y. KANAMORI,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • H. ITAMOCHI,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • T. OISHI,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • Y. MINAGAWA,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • K. ISHIHARA,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • Y. TAKEUCHI,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • M. OKADA,

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author
  • N. TERAKAWA

    1. *Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan;Department of Obstetrics and Gynecology, Tottori Central Prefecture Hospital, Tottori, Japan;Department of Obstetrics and Gynecology, Yonago National Hospital, Yonago, Japan;§Department of Obstetrics and Gynecology, Mihara Red Cross Hospital, Mihara, Japan;andDepartment of Obstetrics and Gynecology, Yamaguchi Red Cross Hospital, Yamaguchi, Japan
    Search for more papers by this author

Address correspondence and reprint requests to: Junzo Kigawa, MD, PhD, Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishimachi, Yonago 683-8504, Japan. Email: kigawa@rape.med.tottori-u.ac.jp

Abstract

Abstract.  Shimada M, Kigawa J, Kanamori Y, Itamochi H, Oishi T, Minagawa Y, Ishihara K, Takeuchi Y, Okada M, Terakawa N. Outcome of patients with early ovarian cancer undergoing three courses of adjuvant chemotherapy following complete surgical staging. Int J Gynecol Cancer 2005;15:601–605.

We conducted the present study to determine the outcome of patients with early ovarian cancer who underwent three courses of adjuvant chemotherapy after complete surgical staging. One hundred consecutive patients with stage I–II epithelial ovarian cancer who had undergone complete surgical staging and received three courses of platinum-based chemotherapy were entered in this study. Twenty-one patients were low risk, defined as stage IA–B, grade 1 and histologic types except for clear cell adenocarcinoma, and remaining 79 were high risk. All patients with stage IA or IB, whatever histologic type and histopathologic grade, were alive without disease. The 5-year survival rate was 89.4% for patients with stage IC and 76.2% for those with stage II. The 5-year survival rate for low- and high-risk patients was 100% and 89.4%, respectively. The survival rate for grade 1 was significantly better than that for grade 2 or 3. Multivariate analysis revealed that histologic grade was an independent prognostic factor in stage IC–II ovarian cancer. The outcome of patients with early ovarian cancer undergoing three courses of chemotherapy after complete surgical staging was favorable even in high-risk patients.

Ancillary