Peter Maguire died October 2006.
The psychosocial impact of human papillomavirus testing in primary cervical screening—a study within a randomized trial
Version of Record online: 18 OCT 2007
© 2007, Copyright the Authors Journal compilation © 2007, IGCS and ESGO
International Journal of Gynecological Cancer
Volume 18, Issue 4, pages 743–748, July/August 2008
How to Cite
KITCHENER, H.C., FLETCHER, I., ROBERTS, C., WHEELER, P., ALMONTE, M. and MAGUIRE, P. (2008), The psychosocial impact of human papillomavirus testing in primary cervical screening—a study within a randomized trial. International Journal of Gynecological Cancer, 18: 743–748. doi: 10.1111/j.1525-1438.2007.01113.x
- Issue online: 14 JUL 2008
- Version of Record online: 18 OCT 2007
- Accepted for publication July 4, 2007
- cervical screening;
The purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20–64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State–Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening.