Abstract Tuberculosis infects someone in the world every second. Although TB is preventable and curable, it has resurfaced as a significant health problem in the U.S., particularly among Latino immigrant groups. In this study of 65 Latino immigrants primarily from Central America, we examined adherence to appointments and medication taking during the six months of preventive therapy for latent TB infection. Findings indicated that the Latinos' adherence to appointment keeping ranged from 81% on the first visit to 59% by the sixth monthly visit. Similarly, medication adherence dropped from 89% in the first month to 64% at six months. Demographic factors, self-assessment of health, other support and presence of side effects were examined in the analysis. Implications for public health nursing are discussed.