Discoid Lupus Erythematosus and X-linked Chronic Granulomatous Disease
Version of Record online: 20 MAR 2008
Volume 3, Issue 5, pages 376–379, November 1986
How to Cite
Barton, L. L. and Johnson, C. R. (1986), Discoid Lupus Erythematosus and X-linked Chronic Granulomatous Disease. Pediatric Dermatology, 3: 376–379. doi: 10.1111/j.1525-1470.1986.tb00544.x
- Issue online: 20 MAR 2008
- Version of Record online: 20 MAR 2008
Abstract: X-linked chronic granulomatous disease (CGD), a defect of leukocyte bactericidal capacity, was seen in three generations of a large kindred. The association of discoid lupus erythematosus (DLE) with CGD was noted. Recurrent antigenic stimulation leading to autoantibody formation may explain the apparently increased frequence of DLE in female carriers of CGD. A screen for CGD, the nitroblue tetrazolium test, is suggested for females with DLE who have experienced suppurative infections or who have a family history of early childhood deaths or recurrent infections.