A Case of Xeroderma Pigmentosum with Clinical Appearance of Dyschromatosis Symmetrica Hereditaria
Article first published online: 20 MAR 2008
Volume 3, Issue 5, pages 410–413, November 1986
How to Cite
Nishigori, C., Miyachi, Y., Takebe, H. and Imamura, S. (1986), A Case of Xeroderma Pigmentosum with Clinical Appearance of Dyschromatosis Symmetrica Hereditaria. Pediatric Dermatology, 3: 410–413. doi: 10.1111/j.1525-1470.1986.tb00552.x
- Issue published online: 20 MAR 2008
- Article first published online: 20 MAR 2008
Abstract: A 9-year-old boy complained of increased freckling on the extremities since very early infancy. Examination showed mottled pigmentation with areas of depigmentation on the backs of the hands and tops of the feet, and less strikingly on the arms and legs. Scattered, small, pigmented freckles on the face were also noticed. The condition was clinically diagnosed as dyschromatosis symmetrica hereditaria (DSH) at first. Unscheduled DNA synthesis was reduced to 66% of the normal value, however, and an ultraviolet sensitivity test by colony formation on fibroblasts revealed moderate sensitivity. Therefore this case was finally diagnosed as xeroderma pigmentosum. It is necessary to study cellular repair capacity to make a precise diagnosis when the distinction is so difficult.