This study was supported by the Orion Corporation Research FoundatioB, Helsinki, Finland.
Percutaneous Absorption of Hydrocortisone During and After the Acute Phase of Dermatitis in Children
Version of Record online: 20 MAR 2008
Volume 5, Issue 4, pages 276–279, November 1988
How to Cite
Turpeinen, M., Lehtokoski-Lehtiniemi, E., Leisti, S. and Salo, O. P. (1988), Percutaneous Absorption of Hydrocortisone During and After the Acute Phase of Dermatitis in Children. Pediatric Dermatology, 5: 276–279. doi: 10.1111/j.1525-1470.1988.tb00904.x
- Issue online: 20 MAR 2008
- Version of Record online: 20 MAR 2008
Abstract: Percutaneous absorption of hydrocortisone was measured by a four hour absorption test in 16 children during and after the acute phase of dermatitis. In the acute phase, after the application of 1% hydrocortisone cream the increment in plasma cortisol ranged from 47 to 961 nmol per liter (median 248 nmol/L). After the acute phase the increment was significantly (P < 0.01< lower: range 18 to 241 nmol per liter (median 95 nmol/L). In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease. Convalescience is connected with a diminished systemic effect due to the restoration of the skin barrier to hydrocortisone.