Melanomas Arising in Large Congenital Nevocytic Nevi: A Prospective Study

Authors

  • Lorraine M. Gari M.D.,

    1. From the Deparimcni of Dermatology, New York University School of Medicine
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  • Jason K. Rivers M.D., F.R.C.P.(C),

    1. Oncology Section, Skin and Cancer Unit, New York University Medical Center; and
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  • Alfred W. Kopf M.D.

    Corresponding author
    1. Melanoma Cooperative Group, New York University Medical Center
      Alfred W. Kopf, M.D. Oncology Seclion. Skin and Cancer tjnit. New York tjniversity Medical Cen-ter, 562 First Avenue, New York, NY 10016.
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Alfred W. Kopf, M.D. Oncology Seclion. Skin and Cancer tjnit. New York tjniversity Medical Cen-ter, 562 First Avenue, New York, NY 10016.

Abstract

Abstract: In 1979 a registry of large (20 cm or more in diameter) congenital nevocytic nevi was established at the NYU Medical Center. To date. 56 patients have been entered. Seven were lost to follow-up. An additional two patients had melanoma on entry into the study and were therefore excluded from the results of prospectively following such patients for the development of melanoma. Thus, this report concerns 47 individuals who were followed prospectively fora mean of 53 months, only 1 of whom developed melanoma. This was a 2-month-oId girl at entry into the study who subsequently developed Tou-raine's syndrome. She eventually developed a primary melanoma in the central nervous system and died of metastatic disease at the age of 21 months.

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