Hypohidrotic Ectodermal Dysplasia: Argument Against an Autosomal Recessive Form Clinically Indistinguishable from X-Linked Hypohidrotic Ectodermal Dysplasia (Christ-Siemens-Touraine Syndrome)

Authors

  • Virginia P. Sybert M.D.

    Corresponding author
    1. Associate Professor, Department of Pediatrics (Medical Genetics), Adjunct Associate Professor, Department of Medicine (Dermatology), University of Washington School of Medicine and Children's Hospital and Medical Center, Seattle, Washington
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Address correspondence to Virginia P. Sybert, M.D., Children's Hospital & Medical Center, Division of Medical Genetics, 4800 Sand Point Way N.E., P.O. Box C5371, Scattle, WA 98105. This work was supported in part by NIH grants AM21557, GM15253, and AR17664.

Abstract

Abstract: Hypohidrotic ectodermal dysplasia (HED) is a welldescribed, X-linked recessive disorder characterized by hypohidrosis, hypodontia, and hypotrichosis in males. Reports of similarly affected females have suggested autosomal recessive inheritance in some families. The evidence for two clinically identical but genetically distinct disorders is not convincing, however. In two families with X-linked recessive inheritance of HED, the condition was severe in females. A critical review of previously reported cases of presumed autosomal recessive HED suggests that an autosomal recessive form of the condition identical to the X-linked HED may not exist. All sporadic instances of females with classic HED should be considered to be X-linked recessive, and counseling for X-linked recessive inheritance as well as autosomal recessive inheritance should be given.

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