Comparison of Crotamiton 10% Cream (Eurax) and Permethrin 5% Cream (Elimite) for the Treatment of Scabies in Children
Version of Record online: 28 JUN 2008
Volume 7, Issue 1, pages 67–73, March 1990
How to Cite
Taplin, D., Meinking, T. L., Chen, J. A. and Sanchez, R. (1990), Comparison of Crotamiton 10% Cream (Eurax) and Permethrin 5% Cream (Elimite) for the Treatment of Scabies in Children. Pediatric Dermatology, 7: 67–73. doi: 10.1111/j.1525-1470.1990.tb01078.x
- Issue online: 28 JUN 2008
- Version of Record online: 28 JUN 2008
Permethrin 5% cream (Elimite) was approved as a treatment for scabies by the U.S. Food and Drug Administration in September 1989. in a doubie-biinded, randomized study, it was compared with crotamiton 10% cream (Eurax) for the treatment of scabies in children 2 months to 5 years of age. Two weeks after a singie overnight treatment, 14 (30%) of 47 chiidren were cured with permethrin 5% cream, in contrast to oniy 6 of 47 (13%) of subjects treated with Eurax. Four weeks after treatment the figures were 89% and 60% cured for the two agents, respectively. In 10 of the 19 patients whose treatment failed, the condition became worse after therapy. The difference in efficacy in favor of permethrin was significant (P = 0.002). That agent also demonstrated greater effectiveness in reducing pruritus and secondary bacterial infections. Eilmite offers a safe, efficacious, and cosmetically elegant aiternative to Eurax in the treatment of scabies in chiidren.