Use of an Emollient As a Steroid-Sparing Agent in the Treatment of Mild to Moderate Atopic Dermatitis in Children
Article first published online: 28 JUN 2008
Volume 14, Issue 4, pages 321–324, July 1997
How to Cite
Lucky, A. W., Leach, A. D., Laskarzewski, P. and Wenck, H. (1997), Use of an Emollient As a Steroid-Sparing Agent in the Treatment of Mild to Moderate Atopic Dermatitis in Children. Pediatric Dermatology, 14: 321–324. doi: 10.1111/j.1525-1470.1997.tb00968.x
- Issue published online: 28 JUN 2008
- Article first published online: 28 JUN 2008
Abstract: The effectiveness of an emollient as an adjunct to topical corticosteroid therapy for the treatment of mild to moderate atopic dermatitis was studied for 3 weeks in 25 children 3 to 15 years of age in comparison with corticosteroid therapy alone. The adjunctive regimen of a once-daily application each of hydrocortisone 2.5% cream and of a water-in-oil cream was equivalent in efficacy to the comparative regimen of twice-daily applications of hydrocortisone 2.5% cream. Both treatment regimens elicited significant improvement in skin condition by day 7 (p < 0.005) and further significant improvement by day 14 (p < 0.005). No significant differences between the two treatment regimens were observed in the rates of improvement (p > 0.545) or in the reductions in mean lesion size (p > 0.9B). No differences were observed in parental evaluations, except for ease of application where a slight preference was expressed for the hydrocortisone 2.5% cream preparation (p < 0.038). We conclude that emollient adjunct i ve therapy offers a steroid-sparing alternative to topical corticosteroids alone in the treatment of mild to moderate atopic dermatitis.